As only a woman’s age and CA125 level are required to determine the cancer probability from our results, this information could readily be incorporated into laboratory information technology (IT) systems, reported alongside the CA125 level, and communicated to patients in clear terms, e.g., “1 in 30 women of your age who have the same CA125 level in general practice will have ovarian cancer.” This evidence concerns the gene MUC16 and ovarian carcinoma.