The previous investigations have shown that PD-1 and PD-L1/PD-L2 belong to the family of immune checkpoint proteins which could induce proliferation and apoptosis in T Cells of cancer patients and causes cancer development (Li et al., 2016; Sacher and Gandhi, 2016, Hashemi et al., 2019). The gene discussed is PDCD1LG2; the disease is cancer.