SOX2 was associated with tumor progression of many tumors such as gastric (Li et al., 2004), pancreatic (Sanada et al., 2006), breast (Rodriguez-Pinilla et al., 2007), colorectal cancers (Han et al., 2012), and osteosarcomas (Basu-Roy et al., 2012). This evidence concerns the gene SOX2 and neoplasm.