Multivariate analysis was performed by using several factors of age <77 years old, albumin level ≥35 g/L, ICGR15 <20 %, Child-Pugh classification A, AFP <100 μg/L, PIVKA-II level <100 mAU/mL, and maximum tumor size <5 cm, which were p<0.1 in univariate analysis. This evidence concerns the gene AFP and neoplasm.