BMF consists of various components that establish a microenvironment for cell differentiation and remodeling, while the signal transducer and activator of transcription (STAT)-3-regulated metabolic pathway was observed to be associated with miR-21 gene expression in chronic lymphocytic leukemia cells (Rozovski et al., 2013; Yue et al., 2016). The gene discussed is STAT3; the disease is B-cell chronic lymphocytic leukemia.