With respect to brainstem and hypothalamic nuclei, neuropeptides such as neuropeptide Y, leptin, or orexins have to be taken into account, that are involved in homeostatic processes (food intake and sleep regulation; (Goadsby et al., 2017)).The occurrence of these signaling systems within the core regions of migraine pathophysiology explains that sleep, food deprivation and stress are frequent trigger factors of migraine attacks. This evidence concerns the gene HCRT and migraine disorder.