With development of dementia, GRN+ carriers showed accelerated loss of volume in portions of the frontal (mean [SD], −1530 [388] mm3 per year for left frontal and −1169 [555] mm3 per year for right frontal ROIs), temporal (mean [SD], −867 [308] mm3 per year for left temporal and −433 [119] mm3 per year for right temporal ROIs), and parietal (mean [SD], −896 [217] mm3 per year for left parietal and −484 [108] mm3 per year for right parietal ROIs) lobes bilaterally. The gene discussed is GRN; the disease is dementia.