IFNA1 and melanoma: In fact, others reported that administration of flutamide increased murine splenocyte proliferation and IFN secretion in response to irradiated murine B16 melanoma cells, and when flutamide was administered with an irradiated B16 vaccine, this combination improved the survival of mice implanted with nonirradiated B16 cells (Hsueh et al., 2003).