As for “canonical” genes involved in melanoma progression, differentiation marker genes such as TyR and TYRP1 were either up- or down-modulated by AR silencing in the various cell lines, and so were the MITF master regulatory gene (Roider and Fisher, 2014) and ZEB2, coding for a transcription factor with a role in melanogenesis upstream of MITF expression (Denecker et al., 2014). The gene discussed is ZEB2; the disease is melanoma.