As observed in vivo, AR localization was largely nuclear in melanoma cells with elevated expression, similar to LnCAP or 22RV.1 prostate cancer cell lines, while in melanoma cell lines or primary melanocytes with low AR levels, there was limited punctate nuclear localization with prevalent perinuclear distribution (Fig. 1 E and Fig. S1 G). The gene discussed is AR; the disease is Familial prostate cancer.