Double immunofluorescence (IF) analysis of melanocytes in benign or dysplastic nevi or metastatic melanoma versus melanocytes from flanking skin showed consistently increased levels of AR expression in the melanocytic lesions, with heterogeneity of AR protein expression at the single-cell level (Fig. 1 A and Fig. S1, A–D). The gene discussed is AR; the disease is metastatic melanoma.