Treatment of different melanoma cell lines with several AR inhibitors, including one that functions through both ligand-competitive and noncompetitive mechanisms, AZD3514 (Loddick et al., 2013), and another, pure ligand competitive inhibitor, enzalutamide (Bambury and Scher, 2015), exerted similar growth-suppressive effects, although at different doses (Fig. 3 A). The gene discussed is AR; the disease is melanoma.