Lnc-MALAT1 expression was negatively associated with expression of inflammatory factors including CRP (P<0.001, r=-0.354) (Figure 3A), TNF-α (P=0.021, r=-0.211) (Figure 3B), IL-6 (P<0.001, r=0.328) (Figure 3C), IL-8 (P=0.037, r=-0.191) (Figure 3D), and IL-22 (P=0.017, r=-0.218) (Figure 3G), while it was positively correlated with expression of anti-inflammatory cytokine IL-10 (P=0.010, r=0.235) (Figure 3E) in AIS patients. The gene discussed is IL22; the disease is androgen insensitivity syndrome.