Considering that lnc-MALAT1 might participate in the cerebrovascular pathologies of stroke according to previous studies, and it presented an anti-inflammatory effect in cardiovascular and cerebrovascular diseases, we hypothesized that lnc-MALAT1 expression might be related to disease risk, progression, or inflammation level of AIS (9–12,25). The gene discussed is MALAT1; the disease is cerebrovascular disorder.