Considering the participation of lnc-MALAT1 in cerebrovascular pathologies of stroke and its anti-inflammation effect on cardiovascular and cerebrovascular diseases, we hypothesized that lnc-MALAT1 might serve as a biomarker for disease risk and progression in AIS via regulating inflammation level, whereas related evidence is seldom reported. This evidence concerns the gene MALAT1 and androgen insensitivity syndrome.