In our study, we assessed the association of lnc-MALAT1 with AIS, and observed that lnc-MALAT1 expression was lower in AIS patients compared to controls, and lnc-MALAT1 expression presented good diagnostic value for AIS, which might be due to its protective effect via repressing cell apoptosis of BMECs in these diseases. Here, MALAT1 is linked to androgen insensitivity syndrome.