CXCL8 and infection: The chemokines CXCL1, CXCL2, leukotriene B4, and interleukin-8 (CXCL8) released during this stage act on leukocyte rolling by inducing stable binding between adhesion molecules and generating a concentration gradient that stimulates the transmigration of neutrophils from the bloodstream to the site of infection (5).