GSDME and hepatocellular carcinoma: Hu et al. (2019) demonstrated that arsenic trioxide (As2O3) NPs could induce pyroptosis in hepatocellular carcinoma Huh7 and HepG2 cells and inhibit tumor growth in a Huh7 xenograft nude mice model through increased caspase‐3 expression and increased Gasdermin E (GSDME) cleavage by caspase‐3 to produce GSDME N‐fragments.