NPPB and cardiovascular disorder: B-type natriuretic peptide (BNP), a 32-amino acid neurohormone produced in and secreted from the heart in response to ventricular dilatation and pressure overload and ischemic injury, has been shown to predict cardiovascular disease (CVD) outcomes in different populations and widely used as a diagnostic and prognostic biomarker for heart failure in clinical practice [2, 3].