It has also been reported to early reflect left ventricular systolic and diastolic dysfunction, while subclinical left ventricular dysfunction is related to the dysfunction of the adrenergic cardiac innervation [4] and implicated in the development of cardiovascular autonomic neuropathy (CAN), one of the main types of diabetic neuropathy, and DPN [5], indirectly indicating that BNP might be associated with the pathogenesis of DPN. The gene discussed is NPPB; the disease is Crouzon syndrome-acanthosis nigricans syndrome.