It is well known that blood pressure and renal function are important factors that may regulate the plasma concentration of natriuretic peptides, and patients with hypertension and DN had elevated plasma levels of BNP [7, 2, 36], and NT-proBNP levels were positively associated with blood pressure levels, especially SBP [2, 28, 30, 36]. The gene discussed is NPPB; the disease is Hypertension.