MAPK8 and cancer: We found BLE as an excellent inhibitor of the liver cancer cell's growth by inducing stress and activating a cascade involving ROS as a second messenger upstream of already known AMPK and JNK pathways [12, 14]; furthermore, it decreased the expression of Bcl-2 that may disturb the Bax/Bcl-2 ratio and completely downregulate mitochondrial membrane potential; it halted the cell cycle at the S and G1 phases to stop the replication and cell division among cancer cells.