Our study supported the oncogenic role of WT1 in myeloid leukemia, and the highlight of this work is the discovery of new WT1 target genes, IL-2, IL-2RB, and IL-2RG, which are likely involved in WT1-mediated leukemogenesis in acute myelogenous leukemia. This evidence concerns the gene IL2RB and acute myeloid leukemia.