In this study, SFEE inhibited the development of AD-like skin lesions and decreases serum IgE and cytokine levels (IL-4, IL-5, IL-10, IL-13, IFN-γ, and TNF-α), while the GK suppressed the expression of IFN-γ and IL-4 in mouse splenocytes [58]. Here, IL4 is linked to Alzheimer disease.