These processes occur during the immune response driven by the SARS-CoV infection and comprise T cell stimulation (ICAM-3, IL-12 RB1), macrophage activation/deactivation (IFN-γ, AHSG), cell trafficking (RANTES, CCL2), RNA degradation and the inhibition of viral replication (OAS-1, MxA), link between humoral and cell-mediated immune reaction (FcgRIIa), virus binding (MLB), and inflammation (TNF-α, CD14) (http://www.genecards.org). The gene discussed is TNF; the disease is severe acute respiratory syndrome.