Through the combination utilization of the statistical analysis methods mentioned above, we finally ascertained that venerable age (≥60 years old), hypertension, lymphopenia, hypoalbuminemia and elevated NLR were the independent high-risk factors associated with the disease severity of COVID-19, and the age, initial lymphocyte count, initial albumin and initial NLR could severe as the independent early predictors for severe COVID-19. This evidence concerns the gene ALB and COVID-19.