To this end, we compared CIN signatures in wild-type patients with those in POLE, CTNNB1, PTEN, PIK3CA, FGFR2 and PPP2R1A mutant patients from subgroups of OB, VBT, EBRT and ICGC PanCancer Analysis of Whole Genomes (PCAWG) (Fig. 2d and Additional file 2: Figure S2). Here, CTNNB1 is linked to cervical squamous intraepithelial neoplasia.