The only exceptional subtype was POLE-mutant, whose prognosis was the best among the four TCGA molecular subtypes, but its CIN signature expression was comparable to that of CNV-H, which had the worst outcome (CIN25: p > 0.05; CIN70: p > 0.05; Fig. 2b, c) [5, 29, 30]. Here, POLE is linked to cervical squamous intraepithelial neoplasia.