Among the TCGA molecular subtypes of EC except POLE-mutant, CNV-L, MSI and CNV-H had the lowest, intermediate and highest risks of recurrence, respectively, and correspondingly had the lowest, intermediate and highest CIN25 and CIN70 (CIN25: p < 0.001; CIN70: p < 0.001; Fig. 2b, c) [5, 29, 30], which once again implied that CIN might positively correlate with the risk of recurrence in EC. This evidence concerns the gene POLE and cervical squamous intraepithelial neoplasia.