POLE and cervical squamous intraepithelial neoplasia: POLE mutant patients in the OB and VBT subgroups did not relapse or die (Fig. 2e) but had higher expression of CIN25 and CIN70 compared with wild-type patients (CIN25: p < 0.05; CIN70: p < 0.05; Fig. 2d), which might interfere with the risk assessment of CIN signatures.