NOTCH1 and coronary artery disorder: We note that, collectively, ultra-rare variants in genes FLT4, ZFAND5, WNT5A, and NOTCH1, were present only in probands with TOF (i.e., not in the other-CHD subgroup), representing significant enrichment (Fisher’s exact test two-sided p-value = 0.01494) compared to background of the total sample.