When applying the constraint threshold, there was one top-associated gene for CHD that did not meet the 10% BH-FDR threshold and that had somewhat similar results in the schizophrenia cohort (OLIG2: CHD uncorrected p-value = 1.39 × 10–4, BH-FDR = 0.181; schizophrenia uncorrected p-value = 0.017) (see Supplementary Table S6). The gene discussed is CHDH; the disease is schizophrenia.