It provided the new evidences for the treatment of cardiovascular diseases with H2S. NLRP3 inflammasome is related to lipid metabolism, and H2S can promote lipolysis 89, so It can be deduced that H2S can promote lipolysis by inhibiting NLRP3 inflammasome against diabetes-accelerated atherosclerosis, which needs further study. The gene discussed is NLRP3; the disease is atherosclerosis.