IL4 and renal fibrosis: In the model of injury and fibrosis of unilateral ureteral obstruction (UUO) mice, exogenous H2S could alleviate macrophage infiltration, tissue fibrosis, and inhibit NF-κB and IL-4/signal transducer and activator of transcription 6 (STAT6) signaling pathways and NLRP3 inflammasome, and NLRP3 inhibitor had the effect similar to that of H2S, which suggested that H2S alleviated renal fibrosis via inhibiting NLRP3 inflammasome.