IPA analysis showed that in vascular SMCs of patients with MI, hypoxia signal of the cardiovascular system was the most important activation pathway, so the researchers also found the up-regulated HIF-1A, UBE2 and CREB1 genes that are associated with the hypoxia signaling pathway, while SOD1 of the aortic wall in MI patients was activated 71. The gene discussed is HIF1A; the disease is myocardial infarction.