IPA analysis showed that in vascular SMCs of patients with MI, hypoxia signal of the cardiovascular system was the most important activation pathway, so the researchers also found the up-regulated HIF-1A, UBE2 and CREB1 genes that are associated with the hypoxia signaling pathway, while SOD1 of the aortic wall in MI patients was activated 71. Here, CREB1 is linked to myocardial infarction.