Seidel et al. demonstrated that when E-cadherin and N-cadherin are stably expressed in an E-cadherin and N-cadherin deficient pancreatic cancer cell line MIA-PaCa-2, only restoration of E-cadherin expression promoted an upregulation in β-catenin levels (Rosivatz et al., 2004). Here, CDH1 is linked to familial pancreatic carcinoma.