CDH1 and cancer: When cancer cells acquire mesenchymal traits and simultaneously express epithelial features, this interphase state is described as hybrid E/M (Kroger et al., 2019). TheCDH1 gene (which encodes the E-cadherin protein and will be referred to as such in the remainder of the manuscript) is the main gene that mediates the epithelial characteristics via binding to the anchoring catenin proteins.