H2BC21 and metabolic syndrome: Several GPs that showed significant fold changes in subjects with metabolic syndrome had also shown similar changes (e.g., increase or decrease) at the end of 4th week during 30-day intermittent fasting (KIT, CROCC, DNTT, POLK, SRGN, CLSTN1) and 1 week after 30-day intermittent fasting (PRKCSH, CALU, SPECC1L, IGFBP4, MYH7, CDH6, H2B histone, PKP1, LRRC3, FGB, ENPP2) in our previous study conducted in healthy subjects although they had not reached statistical significance15.