AKT3 and thyroid cancer: The depletion of Akt2 or Akt3 did not change the tumor incidence or capsular invasion in comparison to PVPV-AktWT mice; however, similar to our prior study using this thyroid cancer model46, PVPV-Akt1KO mice had a trend toward a delay in thyroid cancer incidence (p = 0.053, Fig. 2A) and a significant delay in capsular invasion (Fig. 2B, p = 0.012).