For example, Akt2 regulates Snail-mediated induction of EMT in colon cancer cells50 and it is anti-apoptotic through phosphorylation of glyceraldehyde-3-phosphate dehydrogenase and decreasing its nuclear translocation in ovarian cancer cells consistent with a tumor promoting effect in these cell types51. The gene discussed is GAPDH; the disease is malignant colon neoplasm.