Finally, the deposits of C1q along with CD59, C3aR and C5aR1 expressions in the initial apparently negative biopsy were confirmed in the second biopsy of group A and B patients (Fig. 6A–T), suggesting that the changes observed in PBx preceded the appearance of prostate cancer and remained after the onset of the neoplastic disease. The gene discussed is C5AR1; the disease is Familial prostate cancer.