According to the latest findings, TP53 mutations in EAC are associated with a so-called genomic catastrophe in at least part of the tumors, which is associated with chromotrypsis41 This mechanism probably affects up to one third of all EACs, so that interactions of TP53 and ITGAV that have been described in other tumor entities (see below) cannot necessarily be transferred to EACs. This evidence concerns the gene ITGAV and neoplasm.