Nuclear clearance and cytoplasmic deposition of a nuclear RNA-binding protein RBM20 in non-dividing cells in the DCM model are analogous to a pathological hallmark of neurodegenerative diseases in which predominantly nuclear RNA-binding proteins such as TAR DNA-binding protein 43 kDa (TDP-43) form cytoplasmic inclusions. The gene discussed is RBM20; the disease is familial dilated cardiomyopathy.