Nuclear clearance and cytoplasmic deposition of a nuclear RNA-binding protein RBM20 in non-dividing cells in the DCM model are analogous to a pathological hallmark of neurodegenerative diseases in which predominantly nuclear RNA-binding proteins such as TAR DNA-binding protein 43 kDa (TDP-43) form cytoplasmic inclusions. This evidence concerns the gene TARDBP and neurodegenerative disease.