CACNA2D1 and cardiac arrhythmia: With respect to arrhythmia, expressions of Ank2, a causative gene of long QT syndrome56, and Gpd1l and Cacna2d1, the causative genes of Brugada syndrome57,58, were affected, which might contribute to the arrhythmogenicity in the heart of the Rbm20S637A/S637A mice.