HAND2 and familial dilated cardiomyopathy: We also found that skeletal muscle genes including Tnni1, Tnni2, Tnnt3, Myl1, Casq1, Jsrp1, Myl6b, and Mybpc2 were significantly upregulated, and DCM-related genes including Hopx, Camk2d, Myl3, Sod2, Lmod2, Mylk3, Myoz2, Ttn, Hand2, Tnnc1, Myh7b, and Ctf1 were significantly downregulated in the heart of the Rbm20S637A/S637A mice (Fig. 6c–d, Supplementary Information spreadsheet 1, 2).