CD8A and chronic obstructive pulmonary disease: COPD pathology is characterised by airway remodelling and inflammatory cell infiltration by the neutrophils, CD8 T lymphocytes and activated macrophages.69 Neutrophils have been implicated in COPD pathogenesis and the extent of neutrophilic infiltration in lung tissues correlates with COPD severity.70,71 Inflammatory factors play a major role in the onset and development of COPD.