Further developments include NF-κB “decoy” oligonucleotides and antisense and small interfering RNA agents.236,237 In addition, NF-κB-deficient mice have been reported to be more prone to sepsis,238 hence complications such as immunosuppression and infection susceptibility caused by long-term NF-κB inhibition must be considered (Table 4). This evidence concerns the gene NFKB1 and infection.