Taken along with the results from this study that FAM83C-AS1 augmented EZH2 protein expression but not mRNA expression in CRC, we proceeded to investigate the underlying mechanism and boldly speculated that FAM83C-AS1 might stabilize EZH2 protein expression through binding to ZRANB1 in CRC tumor cells. Here, ZRANB1 is linked to colorectal carcinoma.