For example, lncRNA HIF1A-AS2 mediates CRC progression through miR-129-5p/DNMT3A (DNA cytosine-5-methyltransferase 3A) axis [18]; LncRNA PCA3 promotes prostate cancer progression through sponging miR-218-5p and modulating HMGB1 (high mobility group box protein 1) [19] and LncRNA OCC-1 suppresses cell growth by destabilizing HuR protein in CRC [20]. This evidence concerns the gene DNMT3A and Familial prostate cancer.