CASP1 and viral infectious disease: These results also suggest that ZBP1 senses fungal pathogens, including C. albicans and A. fumigatus, and may form a PANoptosome complex similar to that observed during bacterial and viral infections along with RIPK1, RIPK3, CASP8, CASP1, and FADD to induce PANoptosis (Fig. 3E).