NFKB1 and acute respiratory distress syndrome: It has been reported that LPS treatment leads to ROS production and NF-κB activation (33), whereas these results hold true of our experimentation with MH-S cell models of ALI, wherein the expression levels of NF-κB (p-p65) in the nucleus were elevated, These aberrant levels of NF-κB(p-p65) were accompanied by increases in LPS concentration and NF-κB (p-p65) nucleation, while enrichment in the miR-99b promoter region was promoted by LPS treatment, which indicted that NF-κB (p65) was recruited to the miR-99b promoter region to promote inflammatory damage in its transcriptional regulatory cells.