Amino acid residues in DRβ1 at positions 11, 13, 71, and 74 and in DQβ1 codon 57 represent established susceptibility loci for rheumatoid arthritis [94], type 1 diabetes [95], and multiple sclerosis [96] that exhibited strong associations with IgG levels for EBV, HHV7, VZV, JCV, and MCV antigens, and in some cases harbored the top signal of all HLA variants. The gene discussed is HLA-DRB1; the disease is multiple sclerosis.