RAS and RAF mutations are implicated in a great portion of malignancies: BRAF V600 mutation is found in 40–60% of melanomas and 10–12% of metastatic colorectal cancer (mCRC), KRAS or NRAS in 55% of mCRC, and KRAS in 20–30% of lung adenocarcinoma [150]. This evidence concerns the gene BRAF and melanoma.