ALK and non-small cell lung carcinoma: In a phase II trial, lorlatinib demonstrated meaningful activity as both first-line and subsequent therapies for ALK-rearranged NSCLC, with an ORR of 90% in treatment-naïve patients, 47% in patients with one previous ALK-TKI treatment, and 38.7% in patients with two or more previous ALK-TKIs treatment [64].