Several genes and pathways (including EGFR family, PI3K/Akt/mTOR, RAS/RAF/MEK/MAPK, autophagy, tumor metabolism, low PTEN, PIK3CA mutations, etc.)have been reported to be associated with lapatinib resistance [90] and may provide inspiration for future HER2-TKI development. The gene discussed is EGFR; the disease is neoplasm.