SIRT3 and neoplasm: SIRT3 can deacetylate and activate various mitochondrial metabolic enzymes involved in TCA and FAO enzymes, including LCAD, 3-hydroxy-3-methylglutaryl CoA synthase 2 (HMGCS2), isocitrate dehydrogenase 2 (IDH2) and glutamate dehydrogenase (GDH) to block the supply of glycolysis to the tumor cells [219].