However, overexpression of miR-195-5p/497–5p has led to a significantly increased in protein expression of Bax in tumor tissues, as well as significantly decreased in protein expression of CD133, EpCAM, Nanog, Oct-4, Sox-2, and Bcl-2, but the protein expression of p65 and extent of p65 phosphorylation did not show any significant changes. The gene discussed is NANOG; the disease is neoplasm.