Compared to those after treatment with overexpression of miR-195-5p/497–5p, the protein expression of p65, extent of p65 phosphorylation, CD133, EpCAM, Nanog, Oct-4, Sox-2, and Bcl-2 in tumor tissues was significantly increased after combined treatment of both miR-195-5p/497–5p overexpression and LPS, with a decline in protein expression of Bax (Fig. 5d-e). The gene discussed is POU5F1; the disease is neoplasm.