This is notable as, although the number of patients involved is small, 5.8% is a sizeable proportion of patients whose gBRCAm could be missed if the criteria for gBRCAm testing in patients with HER2-negative metastatic breast cancer are based on the presence of risk factors, including family history of breast and/or ovarian cancer, as well as other tumor types such as prostate and pancreatic cancer [22]. The gene discussed is ERBB2; the disease is ovarian cancer.