Next, to validate if the PKB pathway as observed in lung cancer cells is also involved in downstream signaling of LPA-RAGE axis in migration and invasion of MDA MB-231 and MCF-7 cells, we pre-treated control and RAGE knockdown MDA MB-231 and MCF-7 cells with PKB inhibitor and studied their migration and invasion on LPA addition. Here, AGER is linked to lung carcinoma.