The immunohistochemical staining of the peritoneal wall tumor sections with Ki67 antibody and its quantitative analysis showed significantly higher levels of Ki67 in tumor sections of nude mice transplanted with control shRNA treated MDA MB-231 and MCF-7 receiving LPA treatments than the RAGE shRNA treated MDA MB-231 and MCF-7 cells (Fig. 5e). This evidence concerns the gene AGER and neoplasm.