Finally, β-catenin overexpression significantly inhibited the decrease in c-MYC and cyclin D1 expression in JARID1B–knockdown CRC cells and rescued the decreased Wnt/β-catenin pathway activity induced by downregulating JARID1B, rescued the proliferation ability in CRC cells with JARID1B downregulation in vivo and in vitro. This evidence concerns the gene KDM5B and colorectal carcinoma.