Finally, β-catenin overexpression significantly inhibited the decrease in c-MYC and cyclin D1 expression in JARID1B–knockdown CRC cells and rescued the decreased Wnt/β-catenin pathway activity induced by downregulating JARID1B, rescued the proliferation ability in CRC cells with JARID1B downregulation in vivo and in vitro. Here, CCND1 is linked to colorectal carcinoma.