NEK2 siRNA was found to inhibit tumor growth in a subcutaneous xenograft mouse model of pancreatic cancer, prolong the survival time in an intraperitoneal xenograft mouse model and efficiently prevent the progression of liver metastasis [51]. Combination of NEK2 siRNA and chemotherapeutic agents may be effective treatment for colorectal cancer [52]. This evidence concerns the gene NEK2 and familial pancreatic carcinoma.