Furthermore, in differentiated squamous cell carcinoma II, the expression of CHN1was increased in cancers with lymph node metastasis compared with that in cancers without lymph node metastasis, indicating that CHN1 is associated with lymph node metastasis and may be a potential molecular marker of tumour metastasis. The gene discussed is CHN1; the disease is metastatic malignant neoplasm in the lymph nodes.