Although some previous studies have reported that a high serum sPD‐L1 level is associated with a poor prognosis in patients with several types of cancer,20, 22, 23, 25, 26 few reports have discussed the relationship between the serum sPD‐L1 level and the clinical outcomes of cancer patients receiving anti‐PD‐1 antibody. The gene discussed is SPDL1; the disease is cancer.