Interestingly, inhibition of either Rho or Rac elicit opposite effects of actin-based repair mechanisms in gastric epithelium (Aihara et al. 2018) and while Rho does not exert much influence on the leading edge of lamellipodia in rat adenocarcinoma cells, its inhibition does unmask a Rac-mediated facilitation of edge growth (El-Sibai et al. 2008). The gene discussed is AKT1; the disease is adenocarcinoma.