While a screen of Rho pathway mRNA transcripts found a significant increase in profilin mRNA expression in autopsied HD patient cortical samples as well as in 13w-old pooled (male + female) R6/2 mouse striatum (but not at 4w), there was no corresponding change in profilin protein expression (Narayanan et al. 2016) and these authors did not explore the phosphorylation status of profilin. This evidence concerns the gene RHO and Huntington disease.