Systematic quantitative proteomics—supported by mass spectrometry—based on striatal tissues from the R6/2 mouse (Hosp et al. 2017) and post-mortem HD patient samples (Ratovitski et al. 2016) revealed a widespread loss of protein function that implicates Rho proteins, actin cytoskeleton signaling, and mitochondria (Ratovitski et al. 2016), as well as proteins related to energy metabolism and cellular transport/cytoskeleton (Wegrzynowicz et al. 2012). Here, RHO is linked to Huntington disease.