Our kinome analysis of striatal tissues identified several candidate pathways (see Supplementary Figs. 5–8) including the Akt/FOXO3 pathway that is neuroprotective in HD (Farina et al. 2017) and CDK2 (which we also observed in our NSC extracts, Fig. 1), thus suggesting a dysregulation of cell cycle regulatory proteins (Sang et al. 2014). Here, CDK2 is linked to Huntington disease.