NOS3 and diabetes mellitus: Our previous reports showed that ACh-provoked myocardial lactate production was more frequently observed in patients with diffuse spasm than in those with focal spasm [54], and that female sex, diabetes, and the − 786T/C single nucleotide polymorphism in endothelial nitric oxide synthase gene were associated with ACh-provoked myocardial lactate production in patients with coronary spasm [86].