The most commonly used model of CNS autoimmunity is experimental autoimmune encephalomyelitis (EAE): induction of cerebral and spinal inflammation by myelin autoantigens, such as myelin oligodendrocyte glycoprotein (MOG), proteolipid protein (PLP) and myelin basic protein (MBP). This evidence concerns the gene MBP and experimental autoimmune encephalomyelitis.