Immunopathology of CNS autoimmune disorders involves breaking of tolerance in both the T and B cell compartments: CNS-directed autoreactive B cells, CD8+ T cells and CD4+ helper T cells (TH1, TH17) infiltrate the CNS along with innate immune cells leading to neurotoxicity and/or inflammatory tissue injury [4] (Fig. 1). Here, CD4 is linked to Autoimmunity.