Neuropathological studies show autoreactive T cell infiltration is a feature of both paraneoplastic forms of autoimmune encephalitis, in which cytotoxic T cells and “onconeural” Abs are directed against intracellular CNS autoantigens, and autoimmune encephalitides characterised by autoantibodies against CNS surface self-antigens, e.g. NMDA receptors, leucine-rich glioma-inactivated protein 1 (LGI1) [66–69]. Here, LGI1 is linked to autoimmune encephalitis.