FOXP3 and Autoimmunity: While this central B cell tolerance develops independently of T cell modulation, autoreactive B cells escaping negative selection in bone marrow or generated in the periphery as a result of somatic hypermutation are normally prevented from causing autoimmunity via B-T cell interaction, most importantly induction of B cell anergy or FoxP3+ regulatory T cells (Treg) [10, 11].