In this context, we investigated for the first time the effects of MET on the overall phenotypic functional activities, including immunometabolic (arginase activity, iNOS activity and LDH release) [19] and protective redox based-biomarkers (catalase and SOD activities) [20], ifCa2+, phagocytosis, and co-operative cytokines (IFN-γ and IL-10) [21] of autologous MOs before and during their crosstalk with breast cancer cells (ER-/PR-/HER2+). This evidence concerns the gene ESR1 and breast cancer.