Another subset of circulating and tumor-associated monocytes endowed with proangiogenic activity, are characterized by the expression of the TIE-2/Tek angiopoietin receptor, Endoglin and VEGF-R2 in the intermediate monocytes subset (moM2, CD14++/CD16+) as confirmed by a genomic analysis [77]. The gene discussed is TIE1; the disease is neoplasm.