Our data are also consistent with the notion that the ZEB family member Zeb2 plays reciprocal roles in CD8+ T cell biology (69) and that it does not compensate for the absence of Zeb1. Further understanding Zeb1-mediated control of adult T cell differentiation may have implications for immunosurveillance, a naturally occurring immune mechanism involving CD8+ T cells and other immune subsets that eradicate tumor cells (70, 71). The gene discussed is ZEB1; the disease is neoplasm.