MLKL (P = 3.39 × 10–10), Fas ligand (FASLG, P = 1.97 × 10–9), and TNF receptor superfamily member 10A, TRAIL receptor, DR4 (TNFRSF10A, P = 2.63 × 10–7) showed higher expression in CASP8-mutant HPV-negative oral cancers than their WT counterparts, suggesting that necroptosis might be a potential pathway to target in CASP8-mutant HNSCCs (Figure 1C). This evidence concerns the gene MLKL and lip and oral cavity carcinoma.