Recently, Zwaveling-Soonawala et al. also identified DCHS1 as one of the candidate genes for sporadic PSIS in 2 young patients: a 9-year-old girl who presented with absent stalk and anterior pituitary, EPP, and hormonal deficiencies and a 2.5-year-old boy with small stalk and anterior pituitary, EPP, and hormonal deficiencies (8). The gene discussed is DCHS1; the disease is autosomal erythropoietic protoporphyria.