High tumor BVD was observed in 43 of 82 patients (52%) and, compared with low tumor BVD, was associated with 4-IHC luminal-B (28% vs 10%, P = .02), whereas low BVD compared with high BVD was associated with ERBB2 overexpression (33% vs 7%, P = .003) (eTable 3 in the Supplement). This evidence concerns the gene ERBB2 and neoplasm.