PTK2 and cancer: Reduced production of these angiocrine signals could govern chemosensitization in malignant cells, resulting in improved therapy efficacy in cancer control.24 Given that overexpression of FAK in many cancer types has led to the development of FAK inhibitors for cancer treatment, analysis of the association between endothelial FAK activation and clinical outcome after chemotherapy could be beneficial in selecting patients with breast cancer who may benefit from such novel therapy.