PTK2 and skin cancer: Deletion of FAK in K14-positive epidermal cells reduces skin cancer progression.17 FAK-kinase inactivation in the endothelium is associated with reduced vascular leakage,18,19 whereas the initiation of tumor angiogenesis is reduced by deletion of endothelial FAK in adult mice.20 In established tumors, loss of EC-FAK does not affect blood vessel density (BVD) but alters DNA damage-induced angiocrine signaling (eg, doxorubicin)21,22,23 and, in particular, reduces EC chemokine production.