PTK2 and cancer: Several studies have linked high tumor FAK expression levels with poor prognosis in cancer,6,9,16,32,33 and others suggest that FAK expression does not correlate with outcome, showing no correlation with prognosis or that low FAK expression levels are associated with poor prognosis.11,13,14,34,35,36,37 For example, a study with 335 node-negative breast cancers indicated improved patient survival with high TC-FAK expression levels.11 The relevance of this finding to our study is limited since 83% of the cohort studied herein was node-positive.