We previously developed a potent dominant negative SARM1 variant and demonstrated that AAV-mediated expression of dominant negative SARM1 strongly protects injured axons from degeneration in the peripheral nervous system (Geisler et al., 2019) and is also effective in a neuroinflammatory model of glaucoma (Ko et al., 2020). The gene discussed is SARM1; the disease is glaucoma.